The Key to Antidepressant Companion is in the Ingredients

By Dr. Nicole Cain ND, MA
Oct 01, 2015
1:57 am

Antidepressant Companion, natural depression treatment, has been designed by our founding Naturopathic Doctor, Dr. Nicole Cain, to help your body and brain function optimally. Our doctor has studied and tapped into her extensive knowledge of nutrition and biochemistry as well as the medical research on natural therapies to bring you the most power packed supplement to help you live your best life.

If you are looking for natural depression treatment, and supplements for depression, you are in the right place. Here are some of the most important ingredients in Antidepressant Companion:

N-Acetyl Cysteine (NAC)

NAC has the ability to help you feel and look younger and do it with a smile on your face. NAC is a powerful antioxidant for the brain and body, helping to restore energy, repair damage from free radicals, and reduce inflammation. It has also been shown in studies to improve mood as well! This ingredient is a vital component of Antidepressant Companion because antidepressant medications can actually increase the number of free radicals in your system and cause oxidative damage. Antidepressant Companion contains the optimal form and dose of NAC to help you balance your brain chemistry, reduce oxidative damage, decrease inflammation in the brain and can help you feel more energetic, focused, and help you get back to living a happy and productive life again.

Coenzyme Q10 (Ubiquinone)

Much like NAC, Coenzyme Q10 (CoQ10) helps you look and feel younger. CoQ10 is like a powerhouse for every single cell in your body. Without it, you feel low energy, brain fog, and muscle weakness. Unfortunately, many antidepressant medications can actually cause a depletion of CoQ10. Signs of low CoQ10 include: anxiety, high blood pressure, chest pain, memory loss, asthma, chronic fatigue, gum disease, migraines, weakness, nerve pain, and more. Antidepressant Companion contains the optimal form and dose of CoQ10 to replace what your antidepressant is depleting, and help you feel more like yourself.


L-Tyrosine is a key ingredient to help you get your libido back! Without tyrosine, your body can’t make dopamine or norepinephrine, two chemicals that are necessary to a sense of pleasure and ability to perform when aroused. When on antidepressants, particularly SSRIs, your body may shift toward production of other brain chemicals instead of dopamine and norepinephrine, leaving your sex drive in the dumps. By providing tyrosine, Antidepressant Companion effectively corrects that balance so that you can produce all of the chemicals needed to be happy in and out of the bedroom.


Magnesium deficiency runs rampant in our society, whether you are on antidepressant medications or not. This mineral is a vital nutrient for maintaining stable moods, calm minds, and healthy sleep. It is also helpful for sore muscles, cramps, and headaches. Magnesium is what is often referred to as a cofactor, or an ingredient that is needed to make chemicals that help our bodies function. This includes chemicals that impact mood and our sleep. By taking Antidepressant Companion, you will ensure that your body always has enough magnesium to operate at its highest levels.


Melatonin helps you sleep like a baby and wake up refreshed and ready for the day! Antidepressants like Prozac (fluoxetine) drain your body of its melatonin which causes difficulty falling asleep and staying asleep. This is why many people who take antidepressants develop insomnia as a side effect. Your body uses melatonin for more than just helping you get a good night of sleep. Melatonin is also an anti-cancer, anti-aging, and an antioxidant. It even regulates reproductive hormones, too!  If you have insomnia or difficulty falling asleep/ staying asleep, fatigue, difficulty focusing and concentrating, brain fog, or irritable bowels, these may be signs that your melatonin stores are low and that replacement melatonin may be beneficial for you. Antidepressant Companion contains the optimal form and dose of melatonin to help you balance your brain chemistry, hormones, and to help you get a good night’s sleep again!

Folate (B9, L-5-MTHF)

Folic acid is the unsung hero of the body. It is like a soccer mom in many ways – it is the hidden force that makes sure everything runs smoothly and on time. From producing hormones and neurotransmitters to helping your body process and use sugar, folic acid is necessary for almost every system in your body and its daily function. Folate is the more effective form of folic acid, and L-5-MTHF is the form that is most useable by the body. Studies show that some people have genetic changes that make them unable to use folate correctly. Even when they supplement with it, they aren’t able to use it and end up with signs of deficiency like anxiety and depression. Our doctors have opted to include the L-5-MTHF form because it allows for a detour around the genetic change, making our folate useable by just about everyone!


Saffron will help put the spice back into your sex life. This delicious culinary spice also has medicinal value. Researchers have studied saffron and found that it helps to reverse two of the main side effects of antidepressants – weight gain and low libido. Saffron helps to control carbohydrate cravings that often increase when taking an antidepressant. It has also been studied for use alongside antidepressants such as fluoxetine (Prozac). These studies showed that it not only reduced depression more than medication alone, but it also significantly improved libido and sexual function. Here at NMHS we love saffron, and we are certain you (and your partner) will too.


Much like folate, copper is needed for most of the daily functions of your body. Also like folate, there are some genetic differences that can change the way your body handles copper and zinc. In fact, these two minerals work together like children on a see-saw. Both have to maintain the right balance or it could send the other one way too high or way too low. Having the right balance of copper in your body will help improve mood and sleep, reduce fatigue and irritability, and even help you with brain fog. Antidepressant Companion provides zinc and copper in an ideal ratio so that you can move about your day with ease.

Ascorbic Acid (Vitamin C)

Yet another antioxidant, Vitamin C helps keep you looking and feeling younger, but is also a necessary nutrient for producing the chemicals that help keep you in a good mood. It helps process the amino acids in Antidepressant Companion into dopamine and norepinephrine, brain chemicals that promote a good mood and healthy sexual function. Who knew this vitamin that everyone uses for colds could be so helpful for your mental and sexual health as well? We did! And that is why we included as part of your one stop shop for powerful mood support.


Erectile dysfunction will be a thing of the past thanks to Citrulline. This amino acid helps to increase production of nitric oxide, a chemical that increases blood circulation and allows for fuller and more sustained erections. Don’t worry ladies, it can still help you too. Citrulline has been studied as a powerful antidepressant all on its own, so you will benefit from it too.


Turmeric is beloved by many worldwide, not only for its flavor but for its medicinal properties. This herb dramatically reduces inflammation and damage from free radicals, both of which happen with depression and the use of antidepressant medications. This herb has actually been studied and shown to decrease the impacts of stress on the brain. While it may not directly work against the side effects you are having from your medication, it helps to prime your body so that all of the other ingredients can work more effectively.

Vitamin D

No supplement that aims to help those who struggle with depression would be complete without Vitamin D. A deficiency of vitamin D has been well researched and documented as a cause of depression. In some cases, such as seasonal depression, a deficiency of this vitamin may be the only cause. Vitamin D is necessary for stable moods and a healthy immune system, helping you to stay happy and healthy throughout the year.

Centella (Gotu kola)

Gotu kola is your best friend for dealing with stress. This medicinal plant helps reduce the production of stress hormones that increase feelings of depression and anxiety. One of the ways it does this is by increasing blood circulation. This allows all of the nutrients housed within Antidepressant Companion to get to all of your cells throughout your brain and body. If turmeric sets the stage for improved health and mood, gotu kola is the director that makes sure all of the actors give the performance of a lifetime.


Zinc works like a spark plug for your body. It is an essential nutrient that is a cofactor in producing hormones and neurotransmitters that are responsible for a happy, healthy mood. If your car has a full tank of gas but no spark plugs won’t get very far .This is the same for a body without Zinc.   If your diet provides all of the amino acids (tyrosine, tryptophan, etc.) to produce neurotransmitters (serotonin, dopamine, norepinephrine, etc.) but not enough zinc to start the process of making them,  you won’t get your mood from depressed to happy. A study published in the Journal of Physiology and Pharmacology demonstrates the low zinc is a clinical marker for depression. Low levels of zinc have also been correlated with increased oxidative stress, a significant contributor to depression.  Antidepressant Companion from Natural Mental Health Supplements ensures that you get enough zinc to produce neurotransmitters from the amino acids both in your diet, and in Antidepressant Companion itself so you won’t be left stranded with a full tank of gas but no spark.


Selenium helps to control your weight by ensuring that your thyroid works optimally. Thyroid hormones help to control your metabolism and energy. Low thyroid often presents with weight gain, fatigue, depression, dry skin, and hair loss. It is probably not surprising that many studies have shown that supplementing with thyroid hormone alone can improve depression. The thyroid gland requires selenium in order to produce active hormone. Antidepressant Companion aims to give your body the tools to restore its own function, so it provides selenium to help promote thyroid function, which in turn will help promote healthy metabolism and energy that often leads to weight loss.


Thiamine is used by every organ in your body to make amino acids, the building blocks for proteins. When you are deficient in Thiamine your muscles and nervous system refuse to work properly giving you that Blah feeling. Or more specifically muscle weakness, fatigue, body pains, chronic fatigue, mood imbalances, sexual dysfunction and other general symptoms of malaise. Antidepressant companion provides you with enough Thiamine so your body can produce acetylcholine and GABA.  Acetylcholine is the chemical messenger that your brain uses to make those aches and pains go away. GABA is the messenger that leads to calmness, resting, and relaxing.  Thiamine works in concert with other B vitamins to make certain your body and mind function properly.


Riboflavin is the vitamin that allows you to make energy! Without it your metabolism will refuse to work, leaving you run down, tired and chronically sleepy. Antidepressant pharmaceuticals strip riboflavin out of your body and while eating leafy greens may help, it’s hard to avoid a deficiency. Research also shows that riboflavin deficiency may lead to depression. The good thing though is you can always tell when you are getting enough Riboflavin, this is the vitamin that turns your pee bright yellow.  Antidepressant companion gives you enough Riboflavin to maximize your energy reserves every day.

Cobalamin (B12)

B12 has become the new happy hour shot for the health conscious. It improves energy and metabolism, helping give our weight loss efforts more of a boost. It does this in many of the same ways that the other B vitamins do (see below). The special thing about B12 is that it is primarily found in animal protein, making it a common deficiency in vegetarians. Without B12, anxiety, depressed mood, fatigue and muscle weakness are common. Antidepressant Companion is formulated to include methyl-B12 because it is better absorbed than other forms, making it easier for your body to turn it into useable energy quickly.

Note: Antidepressant Companion is Out of Stock, for now we are recommending Mood Food by Xymogen.


This article is for educational purposes only and is not intended as medical advice. Whenever considering changing your protocol whether it includes a change of medications, supplements, diet or lifestyle, always speak with your primary care physician first.

Dr. Nicole Cain is an advocate for empowering people around the world to help themselves via her educational free resources, online courses, and membership group. You can receive the tools you need to find the root cause of your symptoms and feel healthy again.