6 Health Benefits of Calcium D-Glucarate

Key Points:

• Supplementation with calcium D-glucarate can calm anxiety by promoting detoxification
• Calcium D-glucarate helps the body detox excess hormones such as estrogen
• Those with high LDL cholesterol may benefit from calcium D-glucarate supplementation
• Calcium D-glucarate has been studied as a strategy to prevent certain types of cancers
• Calcium D-glucarate is generally very well tolerated with limited side effects

Do you struggle with anxiety, difficult periods, high cholesterol, or sluggish liver detox? If so, you’re going to want to know about calcium D-glucarate (CDG). 

Calcium D-glucarate is a natural compound found in many fruits and vegetables, and you can buy it as a supplement which is made by combining d-glucaric acid with calcium. There are many benefits to taking with CDG and it’s about to become your favorite supplement. 

In this article we’re going to explore: 

• What is calcium D-glucarate? 
• What is calcium D-glucarate good for?
• How does calcium D-glucarate work?
• Are there any side effects from calcium D-glucarate?

Calcium D-Glucarate Checklist: Signs that CDG might be helpful for you

What is calcium D-glucarate good for?

Over recent years, research has been published supporting calcium D-glucarate as a viable supportive nutrient for many different kinds of health conditions. CDG works primarily by supporting detoxification, which important for the health of your mind and body. 

Here are our top 6 favorite health benefits of calcium D-glucarate:

1. Supporting mental health and mood: Studies suggest that CDG may have mood-boosting properties and may help reduce anxiety and depression symptoms. This may be due to its ability to calm the nervous system, as well as support the body’s natural detoxification pathways and reduce inflammation, all of which affect levels of anxiety and depression.
2. Supporting liver detoxification: CDG can help support the liver’s natural ability to eliminate toxins from the body. By supporting the body’s natural detoxification pathways, it can help promote optimal liver health.
3. Hormone balance: CDG is known for its ability to support the body’s natural elimination of excess estrogen. There is a relationship between anxiety and estrogen levels. Research suggests that fluctuations in estrogen levels may contribute to the development or worsening of anxiety symptoms in some individuals. In women, estrogen levels naturally fluctuate throughout the menstrual cycle, with levels typically highest during the follicular phase (the first half of the cycle) and lowest during the luteal phase (the second half of the cycle). Some women may experience more severe anxiety symptoms during the luteal phase and experience relief from anxiety once estrogen levels are balanced.
4. Reducing inflammation: Some studies suggest that CDG may have anti-inflammatory properties, which can help reduce inflammation throughout the body. This, in turn, may help reduce the risk of chronic diseases like heart disease, diabetes, and cancer.
5. Supporting cardiovascular health: CDG has been shown to help reduce levels of LDL (bad) cholesterol in the blood, which can help support cardiovascular health.
6. Boosting the immune system: Some research has suggested that CDG may have immune-boosting properties, which can help protect the body against infections and disease.

How does calcium D-glucarate work?

Calcium D-glucarate has been shown to support the body’s natural detoxification processes, particularly in the liver. The liver is responsible for breaking down toxins and eliminating them from the body, and CDG may help enhance this process.

One way CDG supports detoxification is by inhibiting an enzyme called beta-glucuronidase. This enzyme can interfere with the body’s ability to eliminate toxins, allowing them to build up in the body over time. Calcium D-glucarate inhibits beta-glucuronidase, allowing the body to eliminate toxins more effectively.

Let’s explore beta-glucuronidase in more detail. 

What is Beta-glucuronidase?

Beta-glucuronidase is an enzyme that is found in the gut microbiome and liver. It plays a role in the metabolism and elimination of certain substances in the body, such as drugs, hormones, and toxins.

In the liver, beta-glucuronidase is involved in a process called glucuronidation. During this process, toxins and other substances are bound to glucuronic acid to make them more water-soluble and easier to eliminate from the body. Beta-glucuronidase can break the bond between the toxin and glucuronic acid, which allows the toxin to be reabsorbed into the body instead of being eliminated.

In the gut, beta-glucuronidase is involved in the breakdown of complex carbohydrates, such as those found in dietary fiber. When levels of beta-glucuronidase are too high, it can lead to the reabsorption of toxins and other substances, which can contribute to various health issues.

Therefore, inhibiting beta-glucuronidase activity can be beneficial for the body’s natural detoxification processes, especially in the liver. This is where calcium D-glucarate may be helpful, as it is known to inhibit beta-glucuronidase activity and promote the elimination of toxins from the body. 

What causes high beta-glucuronidase?

There are many factors that can cause high levels of beta-glucuronidase, including:

• Gut dysbiosis: Gut dysbiosis, which is an imbalance in the gut microbiota, can lead to increased levels of beta-glucuronidase. When the gut microbiota is imbalanced, harmful bacteria can thrive and produce beta-glucuronidase, which can then interfere with the body’s detoxification process. This can cause a myriad of trickle-down symptoms in your hormones, neurotransmitters, and immune system. 
• Medications: Some medications, such as antibiotics, steroids, and non-steroidal anti-inflammatory drugs (NSAIDs), can increase beta-glucuronidase levels in the body.
• Liver dysfunction: Liver dysfunction, which can be caused by factors such as alcohol abuse, hepatitis, or fatty liver disease, can lead to increased levels of beta-glucuronidase.
• Environment: Environmental factors, such as diet, medication use, and exposure to toxins, can also play a role in beta-glucuronidase activity. 
• Genetics: Some people may have a genetic predisposition to higher levels of beta-glucuronidase. In particular, certain genetic polymorphisms in the UGT1A gene, which is involved in the production of beta-glucuronidase, have been linked to increased beta-glucuronidase activity.

What are the effects of high beta-glucuronidase?

High levels of beta-glucuronidase can interfere with the body’s detoxification process by causing toxins and hormones to be reabsorbed into the bloodstream instead of being eliminated from the body. This can lead to a range of health issues, including hormonal imbalances, inflammation, and increased risk of certain diseases. This is where circle back to calcium D-glucarate. Supplementation with CDG can support detoxification by reducing beta-glucuronidase and support overall health and resilience.

Is calcium d-glucarate safe to take?

Calcium D-glucarate is generally considered safe for most people when taken at recommended doses. It is a naturally occurring compound that is found in small amounts in some fruits and vegetables, and it is also produced by the human body.

However, as with any supplement, there are some potential side effects and interactions to be aware of. Some people may experience digestive side effects such as bloating, gas, or diarrhea when taking CDG. In rare cases, allergic reactions have been reported.

Additionally, CDG may interact with certain medications, including estrogen-containing medications, chemotherapy drugs, immunosuppressive drugs, blood thinners, statins, and antibiotics. Therefore, it is important to talk to a healthcare provider before taking calcium D-glucarate if you are currently taking any medications.

It is important to note that this list is not exhaustive, and there may be other medications that can interact with CDG. Always talk to a healthcare provider before taking any new supplements or medications to avoid potential interactions or adverse effects.

Calcium D-Glucarate Containing Foods:

The Best Calcium D-Glucarate Supplements:

There are many calcium D-glucarate supplements available on the market, and choosing the best one can depend on individual needs and preferences. Here are some factors to consider when choosing a CDG supplement:

• Quality: Look for a supplement that is made by a reputable manufacturer and has been tested for purity and potency.
• Form: CDG supplements come in various forms, such as capsules, tablets, and powders. Choose the form that is easiest for you to take and fits your lifestyle.
• Dosage: The recommended dosage of CDG can vary depending on the condition being treated. It is important to follow the dosage instructions on the supplement label or as recommended by a healthcare provider.
• Additional ingredients: Some CDG supplements may contain additional ingredients, such as vitamin C or milk thistle, which can have additional health benefits.

Based on these factors, here are some highly-rated CDG supplements:

• Calcium D-Glucarate by Designs for Health: This supplement contains 1.5 g of calcium D-glucarate per capsule.
• Calcium D Glucarate 200mg by Life Extension: This supplement contains 200 mg of calcium D-glucarate per capsule.
• Calcium D-Glucarate by Jarrow Formulas: This supplement contains 500 mg of calcium D-glucarate per capsule.
• Calcium D-Glucarate by Klaire Labs: This supplement contains 500 mg of calcium D-glucarate per capsule.

You can find all of these supplement options at my supplement shop here!

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Concluding remarks

If you struggle with issues related to your mood, estrogen, and detoxification you just might consider adding CDG to your protocol. My favorite start is to add calcium D-glucarate-containing foods to each meal, and then taking a supplement if necessary.